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Research |
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Healthy Brain Project (PI: C. Rosano) Goal: identify brain networks and risk factors important for maintaining mobility. 327 older adults living in the community, participants of the Health ABC study since 1996, had 1 MRI in 2006-07.They are being followed yearly through 2011. MRIs: include DTI, MTI, Resting State, MPRAGE and FLAIR.
Healthy Brain Project 2 (PIs: C. Rosano, H.J. Aizenstein) Goal: identify markers of resilience to aging and protective factors. Approx 250 HBP survivors, receive 2nd MRI in 2010-11 and will be followed through 2014. MRI include fMRI tasks and arterial spin labeling in addition to the Healthy Brain Project MRI sequences.
EDC & Brain (PI: C. Rosano) Goal: identify markers and risk factors for accelerated brain aging. Approx. 200 middle aged T1D patients who have participated to the EDC study since 1985, will receive MRI and NP tests in 2011. Patients will be followed through 2014. MRI include new fMRI tasks in addition to the Healthy Brain Project-2 MRI sequences. Data will be compared to MRI of older adults and of middle aged without diabetes.
GRACE(PI: C. Rosano) Goal: apply mathematical algorithms to identify brain networks related to mobility patterns. Secondary analysis of existing data. Collaboration with Departments of Math, BME, Computer Science, Biostatistics, and the Simulation and Modeling (SAM) group.
HUGE Brain HUman GEnetics of the Brain (PI: E. Sibille) Goal: identify genes important for preserving cognition, mood and mobility. Secondary analysis of existing data from CHS and Health ABC.
Brain & Balance (PI: P.Sparto) Goal: identify brain networks important for balance control. Approximately 100 older adults are being recruited. |
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Descriptive Studies |
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Intervention Studies |
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LIFE-7MRI. (PI: C. Rosano) Goal: can the brain modify the response to physical activity in sedentary old adults? 75 participants of the RCT LIFE-MAIN, (PIs: Pahor/Newman/Studenski) receive a 7Tesla MRI and will be followed for 2 years.
Dance Dance Revolution. (PIs: C. Rosano and K. Erickson): Goal: can a 3 months dance program improve brain function and structure? 70 post-menopausal women participating in the DDR study (PI: Studenski) |
